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KMID : 0363219710090020035
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Korean Journal of Dermatology
1971 Volume.9 No. 2 p.35 ~ p.40
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Xepoderma Pigmentosum Complicated by Squamous Cell Epithelioma and its Treatment with Bleomycin
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金豊明/Kim, Poong Myung
洪在益/任壽德/Hong, Jae Ik/Lim, Soo Duk
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Abstract
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Xeroderma pigmentosum, a rare, genetically determined dermatosis, is often complicated by malignant chagnes of various types-most commonly, basal-cell epithelioma, squamous cell epithelioma, less frequently malignant melanoma, keratoacanthoma., fibrosarcoma, and endothelioma have been reported.
In Korea, no case has ever been reported in literature except four cases at a symposium for dermatology, two of them complicated by basal-cell epithelioma, and the others by squamous cell epithelioma. This case reported was complicated by squamous cell epithelioma. As one of the anticancer treatments, especially for skin cancer, Bleomycin is, now, drawing the attention for its high therapeutic index with only few side effects.
For this case, we injected Bleomycin 15mg at once, twice a week, for weeks. So total injection was 16 times and 240mg of Bleomycin was given in total. `chile this amount given for this case was not enough for the complete treatment of squamous cell epithelioma, we got the following results:
1. Clinically, the ulcerated lesion of the cancer on the right ala nasi had shrunken in size with reepithelialization at the margin showing clear surface, and
2. microscopically, the atypical cancer cell masses and individual cell keratinizations had been decreased in size and in number, and less remarkable comparing to those in untreated stage at his first visit to the hospital.
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